The major theme of our laboratory is to uncover novel mechanisms that control immune gene expression and their impact on infection and autoimmunity. Specifically, we are interested in identifying post-transcriptional regulators of innate immune genes that include RNA-binding proteins and non-coding RNAs. Individual interactions between non-coding RNAs and protein-coding transcripts are incredibly important, and this level of gene regulation is just beginning to be understood. However, current understanding does not adequately represent the full complexity of these regulatory events. We aim to characterize the complexity of these pathways by coupling robust computational approaches with functional studies to obtain a composite view of the total RNA “regulome.” In the past few years, we have made some major strides in understanding basic molecular mechanisms regulating immune genes in diseases such as hepatitis C viral infection, systemic lupus erythematosus and type 1 diabetes. Our laboratory has extensive experience in the study of post-transcriptional regulation of immune genes, genetics and genomic analysis.
Create your own unique website with customizable templates.