Human susceptibility to virus infections encoded in our genomes Our lab studies human genetic variations and RNA-regulatory mechanisms to gain insights into the heterogeneity in immune responses against viral infections. The major interest is to identify functional variants found in the coding and non-coding regions that determine susceptibility or resistance to life-threatening viral infections. We utilize interdisciplinary approaches including human genetics, comparative immunology, biochemical and molecular biology to investigate how genetic variations could influence virus clearance. The areas of current interest are mRNA splicing induced immune diversity, mRNA translation control, and the role of non-coding RNA in pathogen sensing. These studies will provide insights into immunological mechanisms and the discovery of new targets for drug development.